Modafinil
Modafinil is a memory-improving and mood-brightening
psycho-stimulant. It enhances alertness and vigilance. Modafinil
is less likely to cause nervousness, anxiety, or excess locomotor activity
- or lead to a hypersomnolent 'rebound effect' than conventional stimulants.
The normal removal half-life of modafinil in humans is between
12 - 15 hours. So it's worth fine-tuning one's dosage plan accordingly.
Whatever be your dosage schedule, we are always available to get you your modafinil.
Increasing numbers of students use modafinil.
Current study suggests modafinil, like its older and
better-tested analogue adrafinil, is a harmless, efficient and well-tolerated
agent. It is long acting and doesn't tend to cause peripheral sensitive
stimulus. Modafinil induces vigilance in part by its action in
the frontal hypothalamus. Its dopamine-releasing action in the nucleus
accumbens is feeble and dose-dependent. Modafinil-induced
vigilance is somewhat antagonized by the endogenous cannabinoid
neurotransmitter anandamide. Modafinil directly stimulates the
receptors.
Modafinil is proving clinically helpful in the cure of
narcolepsy, a neurological disorder marked by unmanageable attacks of daytime
drowsiness. Narcolepsy is caused by dysfunction of a family of
wakefulness-promoting and sleep-suppressing peptides, the orexins. Orexin
neurons are activated by modafinil. Orexinergic
neurons are found solely in the lateral hypothalamic area. Their activation is
associated with enhanced delight seeking and enthusiasm as well as excitement.
Orexinergic fibers project to the total central nervous system. Hereditarily
modified orexin-knockout animals offer a model of human narcolepsy.
Narcoleptics suffer intense disturbances in normal sleeping patterns and
variable degrees of dejection. These symptoms can be reversed with modafinil.
Selective orexin receptor agonists of the future may prove helpful both to
narcoleptics and the people at large. Extended insomnia weakens immune
function.
Experimentally, modafinil is also used in the cure of
Alzheimer's disease; depression; attention-deficit disorder (ADHD); myotonic
dystrophy; compound sclerosis-induced tiredness; post-anaesthesia fatigue;
cognitive mutilation in schizophrenia; spasticity associated with cerebral
palsy, age-related memory loss; idiopathic hypersomnia; methamphetamine abuse;
indifference in the aged; jet-lag; cancer-associated weariness and
opioid-induced sedation; exhaustion in Charcot-Marie-Tooth Disease (CMT); and
everyday cat-napping.
There is unsure proof that modafinil may be neuroprotective
against the "dopamine-deficiency disorder" Parkinson's disease. Depressives who
feel drowsy and exhausted can enhance their treatment with modafinil.
Modafinil is used experimentally in the healing of "atypical"
depression. Atypical depression is marked by hypersomnia, over-eating, low
energy, and rejection-sensitivity. The syndrome is in fact pretty common. The
results of preliminary studies have been cheering, but large-scale trials are
required.
Modafinil is increasingly used as a 'lifestyle drug' and its
makers are not unduly eager to discourage this trend. Modafinil
comes as a tablet to be taken by mouth. It is usually taken once a day, with or
without food. You should take modafinil at the same time
everyday. Do not change the time of day that you take modafinil
without talking to your doctor.
|